The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

Wnt signaling is an evolutionary cell‐to‐cell coordination mechanism and it is highly critical
for a variety of physiological processes of an organism's body, including stem cell …

INTRODUCTION Stem cell–derived organoids are in vitro tissue and organ mimetics that
have enormous potential as models for human organ development and disease, as …

Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …

Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …

Intestinal organoids are complex three-dimensional structures that mimic the cell-type
composition and tissue organization of the intestine by recapitulating the self-organizing …

Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …

The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication
system that is important for stem cell renewal, cell proliferation and cell differentiation both …

The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …