Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

Interindividual variability in drug disposition is a major cause of lack of efficacy and adverse
effects of drug therapies. The majority of hepatically cleared drugs are metabolized by …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Background: Coffee is one of the most widely consumed beverages. We tested the
hypothesis that genetically high coffee intake is associated with low risk of obesity, metabolic …

Tobacco smoke contains a large number of compounds in the form of metals, volatile gases
and insoluble particles, as well as nicotine, a highly addictive alkaloid. Marijuana is the most …

Pyrimidine (imatinib, dasatinib, nilotinib and pazopanib), pyridine (sorafenib) and pyrrole
(sunitinib) tyrosine kinase inhibitors (TKIs) are multi-targeted TKIs with high activity towards …

Abstract Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only
metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also …

We report the first genome-wide association study of habitual caffeine intake. We included
47,341 individuals of European descent based on five population-based studies within the …

It is well recognized that herbal supplements or herbal medicines are now commonly used.
As many patients taking prescription medications are concomitantly using herbal …

Epidemiological studies have revealed that caffeine consumption during pregnancy is
associated with adverse gestational outcomes, yet the underlying mechanisms remain …