Polymorphism in molecular crystals is a prevalent phenomenon and is of great interest to the
pharmaceutical community. The solid-state form is a key quality attribute of a crystalline …

Diamond and graphite are polymorphs of each other: they have the same composition but
different structures and properties. Many other substances exhibit polymorphism: inorganic …

The solid form screening of galunisertib produced many solvates, prompting an extensive
investigation into possible risks to the development of the favored monohydrate form …

Ostwald proposed that the solid first formed on crystallisation of a melt or a solution would be
the least stable polymorph. It is shown that this can be rationalized on the basis of …

Water is one of the most important substances on our planet. It is ubiquitous in its solid,
liquid and vaporous states and all known biological systems depend on its unique chemical …

This contribution addresses the role of water molecules in crystal engineering by studying
the crystal structures and thermal stabilities of 11 new cocrystal hydrates, all of which were …

Crystalline solid solutions are long-known solid phases that enable the fine tuning of a
material's structure and properties. Some of them, like metal alloys, have been employed in …

sons for enhanced residual solvent contents. High amounts of solvents can more or less
“dissolve” in these highly energetic metastable areas. Unlike in the liquid-like amorphous …

The pharmaceutical co-crystal approach has been introduced recently to address poor
physicochemical properties of new chemical entities. In this study we prepared and …

The potential impact of changing crystal forms during late-stage drug development, in terms
of cost and product delay, justifies systematic and early characterization of polymorphism. A …