As a chemical transmitter in the mammalian central nervous system, nitric oxide (NO) is still
thought a bit of an oddity, yet this role extends back to the beginnings of the evolution of the …

This review covers recent developments in the cellular neurophysiology of retrograde
signaling in the mammalian central nervous system. Normally at a chemical synapse a …

Since the observation that nitric oxide (NO) can act as an intercellular messenger in the
brain, the past 25 years have witnessed the steady accumulation of evidence that it acts pre …

Throughout the brain, postsynaptic neurons release substances from their cell bodies and
dendrites that regulate the strength of the synapses they receive. Diverse chemical …

Plasticity is a universal property of synapses. It is expressed in a variety of forms mediated
by a multitude of mechanisms. Here we consider two broad kinds of plasticity that differ in …

The molecular and chemical properties of neuronal nitric oxide synthase (nNOS) have made
it a key mediator in many physiological functions and signaling transduction. The NOS …

Homosynaptic Hebbian-type plasticity provides a cellular mechanism of learning and
refinement of connectivity during development in a variety of biological systems. In this …

Spike timing-dependent plasticity (STDP) and other conventional Hebbian-type plasticity
rules are prone to produce runaway dynamics of synaptic weights. Once potentiated, a …

The development of small molecule modulators of NO/cGMP signaling for use in the CNS
has lagged far behind the use of such clinical agents in the periphery, despite the central …

In this study, we investigated the mechanisms underlying synaptic plasticity at the layer IV to
II/III pathway in barrel cortex of mice aged 6–13 weeks. This pathway is one of the likely …