Inhibitory neurotransmission plays a key role in anxiety disorders, as evidenced by the
anxiolytic effect of the benzodiazepine class of γ-aminobutyric acid (GABA) receptor …

Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlap** behavioral phenotypes, which suggests …

Rapidly growing empirical evidence supports the hypothesis that the cortex operates near
criticality. Although the confirmation of this hypothesis would mark a significant advance in …

N-methyl-D-aspartate receptor (NMDAR) excitotoxicity is implicated in the pathogenesis of
Huntington's disease (HD), a late-onset neurodegenerative disorder. However, NMDARs …

Chemical synapses are asymmetric intercellular junctions that mediate synaptic
transmission. Synaptic junctions are organized by trans-synaptic cell adhesion molecules …

Autism spectrum disorder (ASD) is a group of developmental disabilities characterized by
impairments in social interaction and communication and restricted and repetitive …

Delineating the molecular basis of synapse development is crucial for understanding brain
function. Cocultures of neurons with transfected fibroblasts have demonstrated the synapse …

Autism genetics: searching for specificity and convergence | Genome Biology Skip to main
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Neurexins (NXs) and neuroligins (NLs) are transsynaptically interacting cell adhesion
proteins that play a key role in the formation, maturation, activity-dependent validation, and …

Shank3 is a postsynaptic scaffolding protein implicated in synapse development and autism
spectrum disorders. The Shank3 gene is known to produce diverse splice variants whose …