Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Basic mechanisms of diabetic heart disease

RH Ritchie, ED Abel - Circulation research, 2020 - ahajournals.org
Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

2023 AHA/ACC/ACCP/ASPC/NLA/PCNA guideline for the management of patients with chronic coronary disease: a report of the American Heart Association …

SS Virani, LK Newby, SV Arnold, V Bittner… - Journal of the American …, 2023 - jacc.org
Abstract Aim The “2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management
of Patients With Chronic Coronary Disease” provides an update to and consolidates new …

Mitochondrial function as a therapeutic target in heart failure

DA Brown, JB Perry, ME Allen, HN Sabbah… - Nature Reviews …, 2017 - nature.com
Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

Nonalcoholic Fatty Liver Disease and the Heart: JACC State-of-the-Art Review

EP Stahl, DS Dhindsa, SK Lee, PB Sandesara… - Journal of the American …, 2019 - jacc.org
Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are both
manifestations of end-organ damage of the metabolic syndrome. Through multiple …

Ferroptosis: the potential value target in atherosclerosis

S Ouyang, J You, C Zhi, P Li, X Lin, X Tan, W Ma… - Cell Death & …, 2021 - nature.com
In advanced atherosclerosis (AS), defective function-induced cell death leads to the
formation of the characteristic necrotic core and vulnerable plaque. The forms and …

Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy

NJ Byrne, NS Rajasekaran, ED Abel… - Free Radical Biology and …, 2021 - Elsevier
Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

MicroRNA-210 controls mitochondrial metabolism and protects heart function in myocardial infarction

R Song, C Dasgupta, C Mulder, L Zhang - Circulation, 2022 - ahajournals.org
Background: Ischemic heart disease remains a leading cause of death worldwide. In this
study, we test the hypothesis that microRNA-210 protects the heart from myocardial …

Reactive oxygen species: a key hallmark of cardiovascular disease

N Panth, KR Paudel, K Parajuli - Advances in medicine, 2016 - Wiley Online Library
Cardiovascular diseases (CVDs) have been the prime cause of mortality worldwide for
decades. However, the underlying mechanism of their pathogenesis is not fully clear yet. It …

Oxidative stress, apoptosis, and mitochondrial function in diabetic nephropathy

S Sifuentes-Franco, DE Padilla-Tejeda… - International journal …, 2018 - Wiley Online Library
Diabetic nephropathy (DN) is the second most frequent and prevalent complication of
diabetes mellitus (DM). The increase in the production of oxidative stress (OS) is induced by …