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Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
Basic mechanisms of diabetic heart disease
Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …
2023 AHA/ACC/ACCP/ASPC/NLA/PCNA guideline for the management of patients with chronic coronary disease: a report of the American Heart Association …
Abstract Aim The “2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management
of Patients With Chronic Coronary Disease” provides an update to and consolidates new …
of Patients With Chronic Coronary Disease” provides an update to and consolidates new …
Mitochondrial function as a therapeutic target in heart failure
DA Brown, JB Perry, ME Allen, HN Sabbah… - Nature Reviews …, 2017 - nature.com
Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …
worsening heart failure. Despite all the available therapies, the condition carries a very poor …
Nonalcoholic Fatty Liver Disease and the Heart: JACC State-of-the-Art Review
Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are both
manifestations of end-organ damage of the metabolic syndrome. Through multiple …
manifestations of end-organ damage of the metabolic syndrome. Through multiple …
Ferroptosis: the potential value target in atherosclerosis
S Ouyang, J You, C Zhi, P Li, X Lin, X Tan, W Ma… - Cell Death & …, 2021 - nature.com
In advanced atherosclerosis (AS), defective function-induced cell death leads to the
formation of the characteristic necrotic core and vulnerable plaque. The forms and …
formation of the characteristic necrotic core and vulnerable plaque. The forms and …
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy
Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …
may increase the risk for heart failure development. This risk evolves from functional and …
MicroRNA-210 controls mitochondrial metabolism and protects heart function in myocardial infarction
Background: Ischemic heart disease remains a leading cause of death worldwide. In this
study, we test the hypothesis that microRNA-210 protects the heart from myocardial …
study, we test the hypothesis that microRNA-210 protects the heart from myocardial …
Reactive oxygen species: a key hallmark of cardiovascular disease
Cardiovascular diseases (CVDs) have been the prime cause of mortality worldwide for
decades. However, the underlying mechanism of their pathogenesis is not fully clear yet. It …
decades. However, the underlying mechanism of their pathogenesis is not fully clear yet. It …
Oxidative stress, apoptosis, and mitochondrial function in diabetic nephropathy
S Sifuentes-Franco, DE Padilla-Tejeda… - International journal …, 2018 - Wiley Online Library
Diabetic nephropathy (DN) is the second most frequent and prevalent complication of
diabetes mellitus (DM). The increase in the production of oxidative stress (OS) is induced by …
diabetes mellitus (DM). The increase in the production of oxidative stress (OS) is induced by …