STAT proteins in cancer: orchestration of metabolism

YJ Li, C Zhang, A Martincuks, A Herrmann… - Nature reviews Cancer, 2023 - nature.com
Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer

M Labrie, JS Brugge, GB Mills… - Nature reviews Cancer, 2022 - nature.com
Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …

Reactive oxygen species in cancer: Current findings and future directions

H Nakamura, K Takada - Cancer science, 2021 - Wiley Online Library
Reactive oxygen species (ROS), a class of highly bioactive molecules, have been widely
studied in various types of cancers. ROS are considered to be normal byproducts of …

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

J Zhang, CM Simpson, J Berner, HB Chong, J Fang… - Cell, 2023 - cell.com
Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …

The influence of cell cycle regulation on chemotherapy

Y Sun, Y Liu, X Ma, H Hu - International journal of molecular sciences, 2021 - mdpi.com
Cell cycle regulation is orchestrated by a complex network of interactions between proteins,
enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation …

Apoptosis deregulation and the development of cancer multi-drug resistance

CM Neophytou, IP Trougakos, N Erin, P Papageorgis - Cancers, 2021 - mdpi.com
Simple Summary Despite recent therapeutic advances against cancer, many patients do not
respond well or respond poorly, to treatment and develop resistance to more than one anti …

Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy

X Yuan, Y Kang, J Dong, R Li, J Ye, Y Fan… - Nature …, 2023 - nature.com
The exogenous excitation requirement and electron-hole recombination are the key
elements limiting the application of catalytic therapies. Here a tumor microenvironment …

The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

The interplay of ROS and the PI3K/Akt pathway in autophagy regulation

L Kma, TJ Baruah - Biotechnology and applied biochemistry, 2022 - Wiley Online Library
Autophagy causes the breakdown of damaged proteins and organelles to their constituent
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …