Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein that is secreted
mostly by immune cells such as neutrophils, macrophages, and dendritic cells. Its production …

Neutrophil gelatinase-associated lipocalin (NGAL) is a small circulating protein that is highly
modulated in a wide variety of pathological situations, making it a useful biomarker of …

Abstract SHP2 inhibitors (SHP2i) alone and in various combinations are being tested in
multiple tumors with overactivation of the RAS/ERK pathway. SHP2 plays critical roles in …

Stroke is the second leading cause of death worldwide; however, the treatment choices
available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted …

Myelin loss with consecutive axon degeneration and impaired remyelination are the
underlying causes of progressive disease in patients with multiple sclerosis. Astrocytes are …

Age-related eye diseases, including dry eye, glaucoma, age-related macular degeneration,
and diabetic retinopathy, represent a major global health issue based on their increasing …

Immune system activation is involved in cardiovascular (CV) inflammation and fibrosis,
following activation of the mineralocorticoid receptor (MR). We previously showed that …

Background Lipocalin-2 (LCN2) is an indicator of the severity of lupus nephritis (LN) and
plays a pivotal role in immune responses, but it is not known if its effect on LN pathogenesis …

Antimicrobial peptides (AMPs) are small molecules produced by a myriad of cells and play
important roles not only in protecting against infections and sustaining skin barrier …

T cells play the most pivotal roles in antitumor immunity; the T-cell proteome and the
differentially expressed proteins in the tumor immune microenvironment have rarely been …