Various cellular processes (including cell motility) are driven by the regulated, polarized
assembly of actin filaments into distinct force-producing arrays of defined size and …

Actin filaments form contractile and protrusive structures that play central roles in many
processes such as cell migration, morphogenesis, endocytosis, and cytokinesis. During …

Intracellular and extracellular mechanical forces affect the structure and dynamics of the
actin cytoskeleton. However, the underlying molecular and biophysical mechanisms …

Cofilin is best known for its ability to sever actin filaments and facilitate cytoskeletal recycling
inside of cells, but at higher concentrations in vitro, cofilin stabilizes a more flexible, hyper …

Actin-based motility demands the spatial and temporal coordination of numerous regulatory
actin-binding proteins (ABPs)[1], many of which bind with affinities that depend on the …

The actin regulatory protein, cofilin, increases the bending and twisting elasticity of actin
filaments and severs them. It has been proposed that filaments partially decorated with …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are the central regulators of
actin filament disassembly. A key function of ADF/cofilin is to sever actin filaments. However …

The actin cytoskeleton orchestrates cell mechanics and facilitates the physical integration of
cells into tissues, while tissue‐scale forces and extracellular rigidity in turn govern cell …

Coarse-grained (CG) models parametrized using atomistic reference data, ie,“bottom up”
CG models, have proven useful in the study of biomolecules and other soft matter. However …

Members of the cofilin/ADF family of proteins sever actin filaments, increasing the number of
filament ends available for polymerization or depolymerization. Cofilin binds actin filaments …