Microbiome-based therapeutics
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …
regimen that mimics the metabolism of the fasting state to induce the production of ketone …
Gut microbiota in human metabolic health and disease
Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …
[HTML][HTML] Developmental trajectory of the healthy human gut microbiota during the first 5 years of life
The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is
established at birth. However, the succession by which different bacteria are incorporated …
established at birth. However, the succession by which different bacteria are incorporated …
[HTML][HTML] Rethinking healthy eating in light of the gut microbiome
Given the worldwide epidemic of diet-related chronic diseases, evidence-based dietary
recommendations are fundamentally important for health promotion. Despite the importance …
recommendations are fundamentally important for health promotion. Despite the importance …
[HTML][HTML] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection
SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …
The maternal microbiome modulates fetal neurodevelopment in mice
Abstract 'Dysbiosis' of the maternal gut microbiome, in response to challenges such as
infection, altered diet and stress during pregnancy, has been increasingly associated with …
infection, altered diet and stress during pregnancy, has been increasingly associated with …
Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations
Y Ni, L Qian, SL Siliceo, X Long, E Nychas, Y Liu… - Cell Metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic dysfunction
for which effective interventions are lacking. To investigate the effects of resistant starch (RS) …
for which effective interventions are lacking. To investigate the effects of resistant starch (RS) …
The healthy microbiome—what is the definition of a healthy gut microbiome?
Use of microbiome-based biomarkers in diagnosis, prognosis, risk profiling, and precision
therapy requires definition of a healthy microbiome in different populations. To determine …
therapy requires definition of a healthy microbiome in different populations. To determine …
Developmental origins of metabolic diseases
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …
as obese, while nearly one-third of children globally experience poor growth and …