The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

With the rapid development of biopharmaceuticals and the outbreak of COVID-19, the world
has ushered in a frenzy to develop gene therapy. Therefore, therapeutic genes have …

Recent studies have revealed the effects of shape on in vivo nanoparticle circulation,
distribution, extravasation, and cellular uptake. Morphology is therefore becoming a key …

Therapy of inflammatory bowel disease (IBD) has been a difficult task in the medical field.
There is a great clinical need for more effective treatments for IBD. Herein, a targeted oral …

Pulmonary infections with Pseudomonas aeruginosa and Burkholderia cepacia complex
(Bcc) are difficult to treat and related with high mortality in some diseases like cystic fibrosis …

C109 is a potent but poorly soluble FtsZ inhibitor displaying promising activity against
Burkholderia cenocepacia, a high-risk pathogen for cystic fibrosis (CF) sufferers. To harness …

The transport of macromolecular drugs such as oligonucleotides into the lungs has become
increasingly relevant in recent years due to their high potency. However, the chemical …

Emerging therapies based on localized delivery of siRNA to lungs have opened up exciting
possibilities for treatment of different lung diseases. Localized delivery of siRNA to lungs has …

The delivery of aptamer modified therapeutic moieties to specific tissue sites has become
one of the major therapeutic choices to reduce the toxicity of inhibitory drugs. Bearing this in …

Allergic airway diseases, with incidence augmenting visibly as industrial development and
environmental degradation, are characterized by sneezing, itching, wheezing, chest …