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Importance Stroke is the fifth leading cause of death and a leading cause of disability in the
United States, affecting nearly 800 000 individuals annually. Observations Sudden …

Background Disorders affecting the nervous system are diverse and include
neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions …

Background Recent evidence suggests a beneficial effect of endovascular thrombectomy in
acute ischaemic stroke with large infarct; however, previous trials have relied on multimodal …

Background Trials of the efficacy and safety of endovascular thrombectomy in patients with
large ischemic strokes have been carried out in limited populations. Methods We performed …

Background Thrombolytic agents, including tenecteplase, are generally used within 4.5
hours after the onset of stroke symptoms. Information on whether tenecteplase confers …

Background Endovascular therapy for acute ischemic stroke is generally avoided when the
infarction is large, but the effect of endovascular therapy with medical care as compared with …

Background Whether thrombectomy alone is equally as effective as intravenous alteplase
plus thrombectomy remains controversial. We aimed to determine whether thrombectomy …

Background Endovascular treatment for anterior circulation ischaemic stroke is effective and
safe within a 6 h window. MR CLEAN-LATE aimed to assess efficacy and safety of …

Background The value of administering intravenous alteplase before endovascular
treatment (EVT) for acute ischemic stroke has not been studied extensively, particularly in …