Anticancer activity of natural and synthetic chalcones
T Constantinescu, CN Lungu - International journal of molecular sciences, 2021 - mdpi.com
Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and
inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells …
inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells …
Medicinal Plant-derived Phytochemicals in Detoxification
The average worldwide human life expectancy is 70 years, with a significantly higher value
in Western societies. Many modern diseases are not associated with premature mortality but …
in Western societies. Many modern diseases are not associated with premature mortality but …
In silico prediction of PAMPA effective permeability using a two-QSAR approach
CT Chi, MH Lee, CF Weng, MK Leong - International journal of molecular …, 2019 - mdpi.com
Oral administration is the preferred and predominant route of choice for medication. As such,
drug absorption is one of critical drug metabolism and pharmacokinetics (DM/PK) …
drug absorption is one of critical drug metabolism and pharmacokinetics (DM/PK) …
[HTML][HTML] Extending the limitations in the prediction of PAMPA permeability with machine learning algorithms
Gastrointestinal absorption is a key factor amongst the ADME-related (absorption,
distribution, metabolism and excretion) pharmacokinetic properties; therefore, it has a major …
distribution, metabolism and excretion) pharmacokinetic properties; therefore, it has a major …
Natural chain-breaking antioxidants and their synthetic analogs as modulators of oxidative stress
Oxidative stress is associated with the increased production of reactive oxygen species or
with a significant decrease in the effectiveness of antioxidant enzymes and nonenzymatic …
with a significant decrease in the effectiveness of antioxidant enzymes and nonenzymatic …
In vitro permeability of saponins and sapogenins from seed extracts by the parallel artificial membrane permeability assay: effect of in vitro gastrointestinal digestion
The permeability of saponins and sapogenins from fenugreek and quinoa extracts, as well
as dioscin and diosgenin, was evaluated by the parallel artificial membrane permeability …
as dioscin and diosgenin, was evaluated by the parallel artificial membrane permeability …
A Shared Perspective on in Vitro and in Vivo Models to Assay Intestinal Transepithelial Transport of Food Compounds
A Hevia, P Ruas-Madiedo, MA Faria… - Journal of Agricultural …, 2023 - ACS Publications
Assessing nutrient bioavailability is complex, as the process involves multiple digestion
steps, several cellular environments, and regulatory-metabolic mechanisms. Several in vitro …
steps, several cellular environments, and regulatory-metabolic mechanisms. Several in vitro …
Development of artificial neural network models to predict the PAMPA effective permeability of new, orally administered drugs active against the coronavirus SARS …
Responding to the pandemic caused by SARS-CoV-2, the scientific community intensified
efforts to provide drugs effective against the virus. To strengthen these efforts, the “COVID …
efforts to provide drugs effective against the virus. To strengthen these efforts, the “COVID …
Identification of human sulfotransferases active towards silymarin flavonolignans and taxifolin
J Vrba, B Papoušková, P Kosina, K Lněničková… - Metabolites, 2020 - mdpi.com
Natural phenolic compounds are known to be metabolized by phase II metabolic reactions.
In this study, we examined the in vitro sulfation of the main constituents of silymarin, an …
In this study, we examined the in vitro sulfation of the main constituents of silymarin, an …
Advances in the prediction of gastrointestinal absorption: Quantitative Structure-Activity Relationship (QSAR) modelling of PAMPA permeability
Gastrointestinal absorption (GI absorption) is a key absorption, distribution, metabolism, and
excretion (ADME) property when the biological effects of substances are evaluated. The …
excretion (ADME) property when the biological effects of substances are evaluated. The …