The deposition of chemical modifications into RNA is a crucial regulator of temporal and
spatial gene expression programs during development. Accordingly, altered RNA …

tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes.
Although composed of different chemistries, more than 40 types of human tRNA …

Background Inflammasome-mediated neuroinflammation plays an important role in the
pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). The …

Spastic paraplegia 50 (SPG50) is an ultrarare childhood-onset neurological disorder caused
by biallelic loss-of-function variants in the AP4M1 gene. SPG50 is characterized by …

Abstract tRNA modifications affect ribosomal elongation speed and co-translational folding
dynamics. The Elongator complex is responsible for introducing 5-carboxymethyl at wobble …

Mitochondria are essential organelles for the maintenance of neuronal integrity, based on
their manifold functions in regulating cellular metabolism and coordinating cell death and …

Abstract Background Neurodevelopmental disorders (NDDs) are heterogeneous,
debilitating conditions that include motor and cognitive disability and social deficits. The …

Increasing evidence suggests that microglial polarization plays an important role in the
pathological processes of neuroinflammation following subarachnoid hemorrhage (SAH) …

Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common
neurodevelopmental disorders and are characterized by substantial impairment in …

Transfer RNA (tRNA) molecules are essential to decode messenger RNA codons during
protein synthesis. All known tRNAs are heavily modified at multiple positions through post …