The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leucoencephalopathy (CADASIL) is the most common heritable cause of stroke and …

STROKE is the third leading cause of death, and vascular dementia the second cause of
dementia after Alzheimer's disease. CADASIL (for cerebral autosomal dominant arteriopathy …

Background Changes in the cerebral hemispheric white matter, detectable with increasing
frequency by modern neuroimaging methods, are associated with aging and conceivably …

Vascular dementia is the second-most cause of dementia, characterized by cerebral infarcts,
white matter lesions, myelin loss and often amyloid angiopathy. Hence, vascular damage is …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is an increasingly recognized autosomal dominant …

Background CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts
and leucoencephalopathy) is commonly overlooked or misdiagnosed owing to its recent …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is an inherited arterial disease of the brain recently …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) has been recently reported as a cause of stroke. It is …

Mutations in Notch3 cause CADASIL (cerebral autosomal dominant adult onset
arteriopathy), which leads to stroke and dementia in humans. CADASIL arteriopathy is …