Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

The incidence of idiopathic nephrotic syndrome (NS) is 1· 15–16· 9 per 100 000 children,
varying by ethnicity and region. The cause remains unknown but the pathogenesis of …

Glomerular disease, be it primary or secondary, occurring in the setting of systemic
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …

Minimal change disease (MCD) is a major cause of idiopathic nephrotic syndrome (NS),
characterized by intense proteinuria leading to edema and intravascular volume depletion …

Idiopathic nephrotic syndrome is the most frequent pediatric glomerular disease, affecting
from 1.15 to 16.9 per 100,000 children per year globally. It is characterized by massive …

Nephrotic syndrome is defined by nephrotic-range proteinuria (≥ 40 mg/m2/hour or urine
protein/creatinine ratio≥ 200 mg/mL or 3+ protein on urine dipstick), hypoalbuminaemia (< …

Nephrotic syndrome is an important chronic disease in children, characterized by minimal
change disease in the majority. Research on pathogenesis has emphasized the importance …

Idiopathic nephrotic syndrome is the most common glomerular disease in children.
Corticosteroids are the cornerstone of its treatment, and steroid response is the main …

Several case reports suggest that rituximab (RTX) could be effective in steroid-dependent
nephrotic syndrome, but RTX efficacy has not yet been studied in a series of patients. Safety …

Rituximab is an established therapy in children with idiopathic nephrotic syndrome to
sustain short-to medium-term disease remission and avoid steroid toxicities. Recent trials …