Significance: Alzheimer disease (AD) is an age-related neurodegenerative disease. AD is
characterized by progressive cognitive impairment. One of the main histopathological …

There is significant evidence that the pathogenesis of several neurodegenerative diseases,
including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia and amyotrophic …

While the insulin receptor (IR) was found in the CNS decades ago, the brain was long
considered to be an insulin‐insensitive organ. This view is currently revisited, given …

Oxidative stress is at the forefront of Alzheimer disease (AD) research. While its implications
in the characteristic neurodegeneration of AD are vast, the most important aspect is that it …

In this report, we compared total and protein-bound thiol levels in the hippocampus and
cerebellum of six Alzheimer's disease (AD) patients and six age-matched control subjects …

Nonstandard abbreviations used: reactive oxygen species (ROS); Alzheimer disease (AD);
superoxide (O2•–); hydrogen peroxide (H2O2); superoxide dismutase (SOD); β-amyloid …

Alzheimer's disease, the major dementing disorder of the elderly that affects over 4 million
Americans, is related to amyloid β-peptide, the principal component of senile plaques in …

Oxidative stress has been implicated as playing a role in neurodegenerative disorders, such
as ischemic stroke, Alzheimer's, Huntington's, and Parkinson's disease. Persuasive …

Alzheimer's disease (AD) is the most common cause of dementia worldwide and is
characterised pathologically by the accumulation of amyloid beta and tau protein …

There is increasing evidence that free radical damage to brain lipids, carbohydrates,
proteins, and DNA is involved in neuron death in neurodegenerative disorders. The largest …