Targeting cancer metabolism in the era of precision oncology
One hundred years have passed since Warburg discovered alterations in cancer
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …
Liquid biopsy enters the clinic—implementation issues and future challenges
Historically, studies of disseminated tumour cells in bone marrow and circulating tumour
cells in peripheral blood have provided crucial insights into cancer biology and the …
cells in peripheral blood have provided crucial insights into cancer biology and the …
[HTML][HTML] Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C
Background Adagrasib, an oral small-molecule inhibitor of mutant KRAS G12C protein, has
shown clinical activity in pretreated patients with several tumor types, including colorectal …
shown clinical activity in pretreated patients with several tumor types, including colorectal …
Visualizing and interpreting cancer genomics data via the Xena platform
MJ Goldman, B Craft, M Hastie, K Repečka… - Nature …, 2020 - nature.com
To the Editor—There is a great need for easy-to-use cancer genomics visualization tools for
both large public data resources such as TCGA (The Cancer Genome Atlas) 1 and the GDC …
both large public data resources such as TCGA (The Cancer Genome Atlas) 1 and the GDC …
A compendium of mutational cancer driver genes
A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to develo** more efficient cancer detection methods and …
transformation. This is key to develo** more efficient cancer detection methods and …
Next-generation characterization of the cancer cell line encyclopedia
Large panels of comprehensively characterized human cancer models, including the
Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to …
Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to …
Cancer immune evasion through loss of MHC class I antigen presentation
K Dhatchinamoorthy, JD Colbert, KL Rock - Frontiers in immunology, 2021 - frontiersin.org
Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's
expressed genes and then transport and display this antigenic information on the cell …
expressed genes and then transport and display this antigenic information on the cell …
[HTML][HTML] Oncogenic signaling pathways in the cancer genome atlas
F Sanchez-Vega, M Mina, J Armenia, WK Chatila… - Cell, 2018 - cell.com
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co …
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co …
[HTML][HTML] UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses
DS Chandrashekar, B Bashel, SAH Balasubramanya… - Neoplasia, 2017 - Elsevier
Abstract Genomics data from The Cancer Genome Atlas (TCGA) project has led to the
comprehensive molecular characterization of multiple cancer types. The large sample …
comprehensive molecular characterization of multiple cancer types. The large sample …
Maftools: efficient and comprehensive analysis of somatic variants in cancer
Numerous large-scale genomic studies of matched tumor-normal samples have established
the somatic landscapes of most cancer types. However, the downstream analysis of data …
the somatic landscapes of most cancer types. However, the downstream analysis of data …