Progress in the field of prosthetic cardiovascular devices has significantly contributed to the
rapid advancements in cardiac therapy during the last four decades. The concept of …

The final common pathway in myocardial infarction and ischemic stroke is occlusion of blood
flow from a thrombus forming under high shear rates in arteries. A high-shear thrombus …

To better understand the mechanisms leading to the formation and growth of mural thrombi
on biomaterials, we have developed a two-dimensional computational model of platelet …

Multiple interacting mechanisms control the formation and dissolution of clots to maintain
blood in a state of delicate balance. In addition to a myriad of biochemical reactions …

Purpose Device-induced blood damage contributes the hemolysis, thrombosis and bleeding
complications in patients supported with ventricular assist device (VAD). This study aims to …

The systems analysis of thrombosis seeks to quantitatively predict blood function in a given
vascular wall and hemodynamic context. Relevant to both venous and arterial thrombosis, a …

Flow patterns and flow-related stresses contribute to the characterization of health risks,
particularly the risk of plaque rupture, posed by a particular atherosclerotic stenosis. Blood …

While cardiovascular device-induced thrombosis is associated with negative patient
outcomes, the convoluted nature of the processes resulting in a thrombus makes the full …

The efficacy of platelet adhesion in shear flow is known to be substantially modulated by the
physical presence of red blood cells (RBCs). The mechanisms of this regulation remain …

In this paper, we present a spatio-temporal mathematical model for simulating the formation
and growth of a thrombus. Blood is treated as a multi-constituent mixture comprised of a …