Countless times each day, the acute inflammatory response protects us from invading
microbes, injuries, and insults from within, as in surgery-induced tissue injury. These …

Practitioners of ancient societies from the time of Hippocrates and earlier recognized and
treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or …

The brain is highly enriched with fatty acids. These include the polyunsaturated fatty acids
(PUFAs) arachidonic acid and docosahexaenoic acid, which are largely esterified to the …

Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic
activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes …

Heterogeneity and high versatility are the characteristic features of the cells of monocyte-
macrophage lineage. The mononuclear phagocyte system, derived from the bone marrow …

The vitamin E family consists of four tocopherols and four tocotrienols. α-Tocopherol (αT) is
the predominant form of vitamin E in tissues and its deficiency leads to ataxia in humans …

Inflammatory responses, like all biological cascades, are shaped by a delicate balance
between positive and negative feedback loops. It is now clear that in addition to positive and …

Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Mounting of the acute inflammatory response is crucial for host defense and pivotal to the
development of chronic inflammation, fibrosis, or abscess formation versus the protective …

Abstract γ-Tocopherol (γT) is a major form of vitamin E in the US diet and the second most
abundant vitamin E in the blood and tissues, while α-tocopherol (αT) is the predominant …