The human stress response

G Russell, S Lightman - Nature reviews endocrinology, 2019 - nature.com
The human stress response has evolved to maintain homeostasis under conditions of real or
perceived stress. This objective is achieved through autoregulatory neural and hormonal …

Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility

JK Gjerstad, SL Lightman, F Spiga - Stress, 2018 - Taylor & Francis
The hypothalamic–pituitary–adrenal (HPA) axis is the major neuroendocrine axis regulating
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …

Molecular mechanisms of glucocorticoid-induced insulin resistance

C Beaupere, A Liboz, B Fève, B Blondeau… - International journal of …, 2021 - mdpi.com
Glucocorticoids (GCs) are steroids secreted by the adrenal cortex under the
hypothalamicpituitary-adrenal axis control, one of the major neuro-endocrine systems of the …

Modular Aptamer Switches for the Continuous Optical Detection of Small‐Molecule Analytes in Complex Media

AA Hariri, AP Cartwright, C Dory, Y Gidi… - Advanced …, 2024 - Wiley Online Library
Aptamers are a promising class of affinity reagents because signal transduction
mechanisms can be built into the reagent, so that they can directly produce a physically …

An antibody-based molecular switch for continuous small-molecule biosensing

IAP Thompson, J Saunders, L Zheng, AA Hariri… - Science …, 2023 - science.org
We present a generalizable approach for designing biosensors that can continuously detect
small-molecule biomarkers in real time and without sample preparation. This is achieved by …

Cortisol and DHEA in development and psychopathology

HS Kamin, DA Kertes - Hormones and behavior, 2017 - Elsevier
Dehydroepiandrosterone (DHEA) and cortisol are the most abundant hormones of the
human fetal and adult adrenals released as end products of a tightly coordinated endocrine …

The glucocorticoid receptor: isoforms, functions, and contribution to glucocorticoid sensitivity

J Lockett, WJ Inder, VL Clifton - Endocrine Reviews, 2024 - academic.oup.com
Glucocorticoids exert pleiotropic effects on all tissues to regulate cellular and metabolic
homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their …

Proteomics reveals the effects of sustained weight loss on the human plasma proteome

PE Geyer, NJ Wewer Albrechtsen… - Molecular systems …, 2016 - embopress.org
Sustained weight loss is a preferred intervention in a wide range of metabolic conditions, but
the effects on an individual's health state remain ill‐defined. Here, we investigate the plasma …

Measuring cortisol in human psychobiological studies

A Levine, O Zagoory-Sharon, R Feldman, JG Lewis… - Physiology & …, 2007 - Elsevier
The steroid cortisol is an extensively studied and important variable in developmental and
other behavioral studies. Cortisol has been assayed by various methods using a range of …

HPA axis‐rhythms

F Spiga, JJ Walker, JR Terry… - Comprehensive …, 2011 - Wiley Online Library
The hypothalamic‐pituitary‐adrenal (HPA) axis regulates circulating levels of glucocorticoid
hormones, and is the major neuroendocrine system in mammals that provides a rapid …