Tissue regeneration is not simply a local repair event occurring in isolation from the distant,
uninjured parts of the body. Rather, evidence indicates that regeneration is a whole-animal …

A pervasive view is that undifferentiated stem cells are alone responsible for generating all
other cells and are the origins of cancer. However, emerging evidence demonstrates fully …

Injury induces systemic responses, but their functions remain elusive. Mechanisms that can
rapidly synchronize wound responses through long distances are also mostly unknown …

Whole-body regeneration of planarians is a natural wonder but how it occurs remains
elusive. It requires coordinated responses from each cell in the remaining tissue with spatial …

Adult pluripotent stem cell (aPSC) populations underlie whole-body regeneration in many
distantly-related animal lineages, but how the underlying cellular and molecular …

Regeneration plays an instrumental role in biological development and damage repair by
constructing and replacing cells, tissues, and organs. Since regenerative capacity declines …

Planarians are flatworms capable of whole-body regeneration, able to regrow any missing
body part after injury or amputation. The extraordinary regenerative capacity of planarians is …

Noncoding RNAs (ncRNAs) are active regulators of a wide range of biological and
physiological processes, including the majority of mammalian reproductive events …

(1) Background: Abnormal repair after alveolar epithelial injury drives the progression of
idiopathic pulmonary fibrosis (IPF). The maintenance of epithelial integrity is based on the …

Single-cell transcriptomics has revolutionised biology allowing the quantification of gene
expression in individual cells. Since each single cell contains cell type specific mRNAs …