The prototype enzymes of the ubiquitous type IA topoisomerases (topos) family are
Escherichia coli topo I (topA) and topo III (topB). Topo I shows preference for relaxation of …

Human topoisomerase III beta (hTOP3B) is the only topoisomerase in the human cell that
can act on both DNA and RNA substrates. Recent findings have emphasized the …

Abstract Recently, World Health Organization declared antimicrobial resistance as the third
greatest threat to human health. Absence of known cross-resistance, new class, new target …

Tuberculosis (TB) caused by Mycobacterium tuberculosis is a leading infectious cause of
death globally. The treatment of patients becomes much more difficult for the increasingly …

A significant threat to global public health is antimicrobial resistance (AMR). The estimated
cause of at least 700,000 deaths each year worldwide is medication-resistant bacterial …

DNA supercoiling is an essential mechanism of bacterial chromosome compaction, whose
level is mainly regulated by topoisomerase I and DNA gyrase. Inhibiting either of these …

Microorganisms evolve resistance to antibiotics as a function of evolution. Antibiotics have
accelerated bacterial resistance through mutations and acquired resistance through a …

The obligate intracellular bacterial pathogen, Chlamydia trachomatis (Ct), has a distinct DNA
topoisomerase I (TopA) with a C-terminal domain (CTD) homologous to eukaryotic SWIB …

Topoisomerase is an essential enzyme which regulates the topological state of DNA
supercoils during replication and transcription. Topoisomerases cleave either one or two …

Type IA topoisomerases relieve torsional stress in DNA by a strand-passage mechanism,
using the strain in the DNA to drive relaxation. The topoisomerase IAs of the Mycobacterium …