Enantioselective catalysis using chiral metal complexes provides one of the most general
and flexible methods for asymmetric synthesis. 1 Metals are known to possess a range of …

Charles Friedel (1832-1899) started a dual scientific career and spent several years of
activities divided between mineralogy at Ecole des Mines and chemical research. 1 The …

Since its discovery more than a century ago, the Friedel–Crafts reaction has manifested itself
as a powerful method for the introduction of carbon substituents to arenes. Despite its …

After more than 125 years, the Friedel–Crafts alkylation is still one of the most studied and
most utilized reactions in organic synthesis. What is the secret of this astonishing success …

Addition and substitution reactions with carbon nucleophiles are fundamental processes in
organic synthesis, and the development of general catalytic asymmetric variants thereof is …

The Friedel–Crafts (F–C) reaction has been a fundamental pillar of both academic and
industrial synthetic organic chemistry since its discovery in 1873. Its success is based on the …

The state-of-the-art in stereoselective synthesis!. Thoroughly revised and updated, this
enlarged second edition offers a plethora of valuable information on methods and reagents …

The Lewis acid-catalyzed addition of electron-rich aromatic compounds to aldehydes,
ketones and imines, the latter of which is known as the aza-Friedel–Crafts reaction (AFCR) …

Angew. Chem. 2001, 113, Nr. 1 WILEY-VCH Verlag GmbH, D-69451 Weinheim, 2001 0044-
8249/01/11301-0165 $17.50+. 50/0 165 only one enantiomer of 3a can be detected by …

In this Account our recent results in relation to the catalytic and stereoselective Friedel-Crafts
(FC) alkylation of indoles are described. Over the last decade, remarkable efforts have been …