Protein export through the bacterial Sec pathway
A Tsirigotaki, J De Geyter, A Economou… - Nature Reviews …, 2017 - nature.com
The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …
export machinery for most proteins that integrate into, or translocate through, the plasma …
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes
TA Rapoport - Nature, 2007 - nature.com
A decisive step in the biosynthesis of many proteins is their partial or complete translocation
across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma …
across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma …
[HTML][HTML] Sec-and Tat-mediated protein secretion across the bacterial cytoplasmic membrane—distinct translocases and mechanisms
In bacteria, two major pathways exist to secrete proteins across the cytoplasmic membrane.
The general Secretion route, termed Sec-pathway, catalyzes the transmembrane …
The general Secretion route, termed Sec-pathway, catalyzes the transmembrane …
Mechanisms of Sec61/SecY-mediated protein translocation across membranes
E Park, TA Rapoport - Annual review of biophysics, 2012 - annualreviews.org
The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
[HTML][HTML] The sec translocase
DJF Du Plessis, N Nouwen, AJM Driessen - Biochimica et Biophysica Acta …, 2011 - Elsevier
The vast majority of proteins trafficking across or into the bacterial cytoplasmic membrane
occur via the translocon. The translocon consists of the SecYEG complex that forms an …
occur via the translocon. The translocon consists of the SecYEG complex that forms an …
The way is the goal: how SecA transports proteins across the cytoplasmic membrane in bacteria
T Cranford-Smith, D Huber - FEMS microbiology letters, 2018 - academic.oup.com
In bacteria, translocation of most soluble secreted proteins (and outer membrane proteins in
Gram-negative bacteria) across the cytoplasmic membrane by the Sec machinery is …
Gram-negative bacteria) across the cytoplasmic membrane by the Sec machinery is …
Molecular simulations of protein dynamics: new windows on mechanisms in biology
Recent advances in computer hardware and software have led to the development of
increasingly successful molecular simulations of protein structural dynamics that are intrinsic …
increasingly successful molecular simulations of protein structural dynamics that are intrinsic …
Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA
The translocon is a membrane‐embedded protein assembly that catalyzes protein
movement across membranes. The core translocon, the SecYEG complex, forms oligomers …
movement across membranes. The core translocon, the SecYEG complex, forms oligomers …
Molecular insight into the steric shielding effect of PEG on the conjugated staphylokinase: biochemical characterization and molecular dynamics simulation
Q Mu, T Hu, J Yu - PLoS One, 2013 - journals.plos.org
PEGylation is a successful approach to improve potency of a therapeutic protein. The
improved therapeutic potency is mainly due to the steric shielding effect of PEG. However …
improved therapeutic potency is mainly due to the steric shielding effect of PEG. However …
Regulation of the protein-conducting channel by a bound ribosome
During protein synthesis, it is often necessary for the ribosome to form a complex with a
membrane-bound channel, the SecY/Sec61 complex, in order to translocate nascent …
membrane-bound channel, the SecY/Sec61 complex, in order to translocate nascent …