Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation
SW Ryter, AMK Choi - Translational Research, 2016 - Elsevier
The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications
SW Ryter, J Alam, AMK Choi - Physiological reviews, 2006 - journals.physiology.org
The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …
Iron overload via heme degradation in the endoplasmic reticulum triggers ferroptosis in myocardial ischemia-reperfusion injury
HD Miyamoto, M Ikeda, T Ide, T Tadokoro… - Basic to Translational …, 2022 - jacc.org
Summary Ischemia-reperfusion (I/R) injury is a promising therapeutic target to improve
clinical outcomes after acute myocardial infarction. Ferroptosis, triggered by iron overload …
clinical outcomes after acute myocardial infarction. Ferroptosis, triggered by iron overload …
Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities
Carbon monoxide (CO) is generated in living organisms during the degradation of heme by
the enzyme heme oxygenase, which exists in constitutive (HO-2 and HO-3) and inducible …
the enzyme heme oxygenase, which exists in constitutive (HO-2 and HO-3) and inducible …
Biliverdin reductase: a major physiologic cytoprotectant
DE Barañano, M Rao, CD Ferris… - Proceedings of the …, 2002 - National Acad Sciences
Bilirubin, an abundant pigment that causes jaundice, has long lacked any clear physiologic
role. It arises from enzymatic reduction by biliverdin reductase of biliverdin, a product of …
role. It arises from enzymatic reduction by biliverdin reductase of biliverdin, a product of …
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
E Balogun, M Hoque, P Gong, E Killeen… - Biochemical …, 2003 - portlandpress.com
The transcription factor Nrf2, which normally exists in an inactive state as a consequence of
binding to a cytoskeleton-associated protein Keap1, can be activated by redox-dependent …
binding to a cytoskeleton-associated protein Keap1, can be activated by redox-dependent …
Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
R Motterlini, R Foresti, R Bassi, CJ Green - Free Radical Biology and …, 2000 - Elsevier
Curcumin, a widely used spice and coloring agent in food, has been shown to possess
potent antioxidant, antitumor promoting and anti-inflammatory properties in vitro and in vivo …
potent antioxidant, antitumor promoting and anti-inflammatory properties in vitro and in vivo …
Ischemia–reperfusion–induced lung injury
Ischemia–reperfusion–induced lung injury is characterized by nonspecific alveolar damage,
lung edema, and hypoxemia occurring within 72 hours after lung transplantation. The most …
lung edema, and hypoxemia occurring within 72 hours after lung transplantation. The most …
Heme oxygenase-1: unleashing the protective properties of heme
Abstract Heme oxygenase (HO)-1 catabolizes heme into three products: carbon monoxide
(CO), biliverdin (which is rapidly converted to bilirubin) and free iron (which leads to the …
(CO), biliverdin (which is rapidly converted to bilirubin) and free iron (which leads to the …
Heme oxygenases in cardiovascular health and disease
Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …