Although dopamine replacement therapy remains a core component of Parkinson's disease
treatment, the onset of motor fluctuations and dyskinetic movements might require a range of …

This systematic review provides supporting evidence for a clinical practice guideline for the
management of rapid eye movement (REM) sleep behavior disorder in adults and children …

The distinguishing pathogenic features of neurodegenerative diseases include
mitochondrial dysfunction and derived reactive oxygen species generation. The neural …

Parkinson's disease (PD) occurs in approximately 1% of the population over 65 years of age
and has become increasingly more common with advances in age. The number of …

While primarily produced in the pineal gland, melatonin's influence goes beyond its well-
known role in regulating sleep, nighttime metabolism, and circadian rhythms, in the field of …

Parkinson's disease (PD) is defined by its motor symptoms rigidity, tremor, and akinesia.
However, non-motor symptoms, particularly autonomic disorders and sleep disturbances …

Sleep complaints can be both common and complex in the older patient. Their consideration
is an important aspect of holistic care, and may have an impact on quality of life, mortality …

Since its first description in 1986 by Dr. Carlos Schenck, and his group's subsequent report
of the delayed emergence of a Parkinsonian disorder in idiopathic RBD patients one decade …

Exogenous melatonin is commonly used for sleep disorders in older adults, and its use is
increasing over time. It appears to have modest efficacy in treating insomnia and circadian …

Parkinson's disease (PD) is a complex, multisystem disorder with both neurologic and
systemic manifestations, which is usually associated with non-motor symptoms, including …