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Circadian disruption, clock genes, and metabolic health
LA Schrader, SM Ronnekleiv-Kelly… - The Journal of Clinical …, 2024 - jci.org
A growing body of research has identified circadian-rhythm disruption as a risk factor for
metabolic health. However, the underlying biological basis remains complex, and complete …
metabolic health. However, the underlying biological basis remains complex, and complete …
Adipogenesis and metabolic health
Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
Molecular Actions of PPARα in Lipid Metabolism and Inflammation
Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …
Crosstalk between metabolism and circadian clocks
Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …
Spatiotemporal metabolic liver zonation and consequences on pathophysiology
Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …
Communicating clocks shape circadian homeostasis
BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …
Feeding rhythms and the circadian regulation of metabolism
The molecular circadian clock regulates metabolic processes within the cell, and the
alignment of these clocks between tissues is essential for the maintenance of metabolic …
alignment of these clocks between tissues is essential for the maintenance of metabolic …
Effect of circadian rhythm on metabolic processes and the regulation of energy balance
Background: The circadian timing system or circadian clock plays a crucial role in many
biological processes, such as the sleep-wake cycle, hormone secretion, cardiovascular …
biological processes, such as the sleep-wake cycle, hormone secretion, cardiovascular …
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
The circadian clock regulates daily rhythms of numerous physiological activities through
tightly coordinated modulation of gene expression and biochemical functions. Circadian …
tightly coordinated modulation of gene expression and biochemical functions. Circadian …
Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism
Certain members of the gut microbiota exhibit diurnal variations in relative abundance and
function to serve as non-canonical drivers of host circadian rhythms and metabolism. Also …
function to serve as non-canonical drivers of host circadian rhythms and metabolism. Also …