The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease
V Rothhammer, FJ Quintana - Nature Reviews Immunology, 2019 - nature.com
The environment, diet, microbiota and body's metabolism shape complex biological
processes in health and disease. However, our understanding of the molecular pathways …
processes in health and disease. However, our understanding of the molecular pathways …
Regulation of the immune response by the aryl hydrocarbon receptor
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is
activated by small molecules provided by the diet, microorganisms, metabolism, and …
activated by small molecules provided by the diet, microorganisms, metabolism, and …
Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut
Breastfeeding profoundly shapes the infant gut microbiota, which is critical for early life
immune development, and the gut microbiota can impact host physiology in various ways …
immune development, and the gut microbiota can impact host physiology in various ways …
Differentiation of effector CD4 T cell populations
CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They
are also involved in autoimmunity, asthma, and allergic responses as well as in tumor …
are also involved in autoimmunity, asthma, and allergic responses as well as in tumor …
Gut-microbiota-derived metabolites maintain gut and systemic immune homeostasis
J Wang, N Zhu, X Su, Y Gao, R Yang - Cells, 2023 - mdpi.com
The gut microbiota, including bacteria, archaea, fungi, viruses and phages, inhabits the
gastrointestinal tract. This commensal microbiota can contribute to the regulation of host …
gastrointestinal tract. This commensal microbiota can contribute to the regulation of host …
Regulation and functions of the IL-10 family of cytokines in inflammation and disease
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family …
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family …
An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells
JD Mezrich, JH Fechner, X Zhang… - The Journal of …, 2010 - journals.aai.org
The aryl hydrocarbon receptor (AHR) has been known to cause immunosuppression after
binding dioxin. It has recently been discovered that the receptor may be central to T cell …
binding dioxin. It has recently been discovered that the receptor may be central to T cell …
Environmental pollutants and the immune response
Environmental pollution is one of the most serious challenges to health in the modern world.
Pollutants alter immune responses and can provoke immunotoxicity. In this Review, we …
Pollutants alter immune responses and can provoke immunotoxicity. In this Review, we …
Interleukin-1 and IL-23 induce innate IL-17 production from γδ T cells, amplifying Th17 responses and autoimmunity
CE Sutton, SJ Lalor, CM Sweeney, CF Brereton… - Immunity, 2009 - cell.com
Summary Th17 cells, CD4+ T cells that secrete interleukin-17 (IL-17), are pathogenic in
autoimmune diseases and their development and expansion is driven by the cytokines IL-6 …
autoimmune diseases and their development and expansion is driven by the cytokines IL-6 …
Plasticity of CD4+ T cell lineage differentiation
The differentiation of naive CD4+ T cells into lineages with distinct effector functions has
been considered to be an irreversible event. T helper type 1 (Th1) cells stably express IFN-γ …
been considered to be an irreversible event. T helper type 1 (Th1) cells stably express IFN-γ …