High-level folding of chromatin is a key determinant of the shape and functional state of
chromosomes. During cell division, structural maintenance of chromosome (SMC) …

IJMS | Free Full-Text | Super-Enhancers and Their Parts: From Prediction Efforts to
Pathognomonic Status Next Article in Journal Constitutional BRCA1 and MGMT Methylation Are …

Cancer cells often experience large-scale alterations in genome architecture because of
DNA damage and replication stress. Whether mutations in core regulators of chromosome …

Cancer chimeric, or fusion, transcripts are thought to most frequently appear due to
chromosomal aberrations that combine moieties of unrelated normal genes. When being …

The R-loop is a common transcriptional by-product that consists of an RNA-DNA duplex
joined to a displaced strand of genomic DNA. While the effects of R-loops on health and …

Structural maintenance of chromosomes (SMC) complexes play a crucial role in organizing
the three-dimensional structure of chromatin, facilitating key processes such as gene …

Simple Summary Upon interferon stimulation, cancer cells upregulate the pro-apoptotic
cytokine TRAIL, but the mechanism of this upregulation remains unresolved. By examining …

The mechanisms underlying breast cancer development are diverse and complex. While the
roles of conventional oncogenes and signaling pathways have been increasingly …

We introduce InGene, the first of its kind, fast and scalable non-linear, unsupervised method
for analyzing single-cell RNA sequencing data (scRNA-seq). While non-linear …