Towards a genomics-informed, real-time, global pathogen surveillance system

JL Gardy, NJ Loman - Nature Reviews Genetics, 2018 - nature.com
Abstract The recent Ebola and Zika epidemics demonstrate the need for the continuous
surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast …

Viral phylodynamics

EM Volz, K Koelle, T Bedford - PLoS computational biology, 2013 - journals.plos.org
Viral phylodynamics is defined as the study of how epidemiological, immunological, and
evolutionary processes act and potentially interact to shape viral phylogenies. Since the …

Early phylogenetic estimate of the effective reproduction number of SARS‐CoV‐2

A Lai, A Bergna, C Acciarri, M Galli… - Journal of medical …, 2020 - Wiley Online Library
To reconstruct the evolutionary dynamics of the 2019 novel‐coronavirus recently causing an
outbreak in Wuhan, China, 52 SARS‐CoV‐2 genomes available on 4 February 2020 at …

Birth–death skyline plot reveals temporal changes of epidemic spread in HIV and hepatitis C virus (HCV)

T Stadler, D Kühnert, S Bonhoeffer… - Proceedings of the …, 2013 - National Acad Sciences
Phylogenetic trees can be used to infer the processes that generated them. Here, we
introduce a model, the Bayesian birth–death skyline plot, which explicitly estimates the rate …

Bayesian coalescent inference of past population dynamics from molecular sequences

AJ Drummond, A Rambaut, B Shapiro… - Molecular biology and …, 2005 - academic.oup.com
We introduce the Bayesian skyline plot, a new method for estimating past population
dynamics through time from a sample of molecular sequences without dependence on a …

How generation intervals shape the relationship between growth rates and reproductive numbers

J Wallinga, M Lipsitch - … of the Royal Society B: Biological …, 2007 - royalsocietypublishing.org
Mathematical models of transmission have become invaluable management tools in
planning for the control of emerging infectious diseases. A key variable in such models is the …

Unifying the epidemiological and evolutionary dynamics of pathogens

BT Grenfell, OG Pybus, JR Gog, JLN Wood, JM Daly… - science, 2004 - science.org
A key priority for infectious disease research is to clarify how pathogen genetic variation,
modulated by host immunity, transmission bottlenecks, and epidemic dynamics, determines …

Perspectives on the basic reproductive ratio

JM Heffernan, RJ Smith… - Journal of the Royal …, 2005 - royalsocietypublishing.org
The basic reproductive ratio, R 0, is defined as the expected number of secondary infections
arising from a single individual during his or her entire infectious period, in a population of …

[PDF][PDF] Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes

P Simmonds, J Bukh, C Combet, G Deléage… - …, 2005 - Wiley Online Library
International standardization and coordination of the nomenclature of variants of hepatitis C
virus (HCV) is increasingly needed as more is discovered about the scale of HCV‐related …

The global epidemiology of hepatocellular carcinoma: present and future

KA McGlynn, WT London - Clinics in liver disease, 2011 - liver.theclinics.com
On the global scale, primary liver cancer is a major contributor to both cancer incidence and
mortality. It is the sixth most commonly occurring cancer in the world and the third largest …