SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

Mechanisms of SARS-CoV-2 transmission and pathogenesis

AG Harrison, T Lin, P Wang - Trends in immunology, 2020 - cell.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks
the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 …

[HTML][HTML] Reduced neutralization of SARS-CoV-2 B. 1.1. 7 variant by convalescent and vaccine sera

P Supasa, D Zhou, W Dejnirattisai, C Liu, AJ Mentzer… - Cell, 2021 - cell.com
SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being
deployed at scale, aiming to generate responses against the virus spike. The scale of the …

The trinity of COVID-19: immunity, inflammation and intervention

MZ Tay, CM Poh, L Rénia, PA MacAry… - Nature Reviews …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into …

Impact of sex and gender on COVID-19 outcomes in Europe

C Gebhard, V Regitz-Zagrosek, HK Neuhauser… - Biology of sex …, 2020 - Springer
Abstract Background Emerging evidence from China suggests that coronavirus disease
2019 (COVID-19) is deadlier for infected men than women with a 2.8% fatality rate being …

COVID-19 pathophysiology: A review

K Yuki, M Fujiogi, S Koutsogiannaki - Clinical immunology, 2020 - Elsevier
In December 2019, a novel coronavirus, now named as SARS-CoV-2, caused a series of
acute atypical respiratory diseases in Wuhan, Hubei Province, China. The disease caused …

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

C Muus, MD Luecken, G Eraslan, L Sikkema… - Nature medicine, 2021 - nature.com
Abstract Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and
CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

SARS-CoV-2 productively infects human gut enterocytes

MM Lamers, J Beumer, J van der Vaart, K Knoops… - Science, 2020 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus
disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the …

The pathophysiology of 'happy'hypoxemia in COVID-19

S Dhont, E Derom, E Van Braeckel, P Depuydt… - Respiratory …, 2020 - Springer
The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging
healthcare systems worldwide. Many patients present with a remarkable disconnect in rest …

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

MY Li, L Li, Y Zhang, XS Wang - Infectious diseases of poverty, 2020 - mednexus.org
Background: Since its discovery in December 2019, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has infected more than 2 180 000 people worldwide and has …