Over 500 natural and synthetic amino acids have been genetically encoded in the last two
decades. Incorporating these noncanonical amino acids into proteins enables many …

Paramagnetic chemical probes have been used in electron paramagnetic resonance (EPR)
and nuclear magnetic resonance (NMR) spectroscopy for more than four decades. Recent …

Damaged mitochondria are detrimental to cellular homeostasis. One mechanism for removal
of damaged mitochondria involves the PINK1-PARKIN pathway, which poly-ubiquitylates …

Since at least the last common ancestor of all life on Earth, genetic information has been
stored in a four-letter alphabet that is propagated and retrieved by the formation of two base …

Cell-free protein synthesis has emerged as a powerful approach for expanding the range of
genetically encoded chemistry into proteins. Unfortunately, efforts to site-specifically …

Organelles are physically connected by membrane contact sites. The endoplasmic reticulum
possesses three major receptors, VAP‐A, VAP‐B, and MOSPD2, which interact with proteins …

The quality of mitochondria, essential organelles that produce ATP and regulate numerous
metabolic pathways, must be strictly monitored to maintain cell homeostasis. The loss of …

The TFE3 and MITF master transcription factors maintain metabolic homeostasis by
regulating lysosomal, melanocytic, and autophagy genes. Previous studies posited that their …

A fundamental feature of cell signaling is the conversion of extracellular signals into
adaptive transcriptional responses. The role of RNA modifications in this process is poorly …

Understanding the functional and structural consequences of site-specific protein
phosphorylation has remained limited by our inability to produce phosphoproteins at high …