For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional
concepts in toxicology, in particular the dogma of “the dose makes the poison,” because …

This review addresses open questions about the role of β-adrenergic receptors in cardiac
function and failure. Cardiomyocytes express all three β-adrenergic receptor subtypes—β1 …

Sympathetic tone is well recognised as being implicit in cardiovascular control. It is less
readily acknowledged that activation of the sympathetic nervous system is integral in energy …

Stimulation of cardiac β1-adrenergic receptors is the main mechanism that increases heart
rate and contractility. Consequently, several pharmacological and gene transfer strategies …

G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …

Persistent organic pollutants (POPs) are lipophilic compounds that travel with lipids and
accumulate mainly in adipose tissue. Recent human evidence links low-dose POPs to an …

Non-monotonic dose response curves (NMDRCs) have been demonstrated for natural
hormones and endocrine disrupting chemicals (EDCs) in a variety of biological systems …

Fluorescence and bioluminescence resonance energy transfer (FRET and BRET)
techniques allow the sensitive monitoring of distances between two labels at the nanometer …

Bone cells are capable of sensing and responding to mechanical forces, but
mechanosensitivity begins to decline soon after the stimulus is initiated. Under continued …