In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

Regulation of cell mortality for disease treatment has been the focus of research. Ferroptosis
is an iron-dependent regulated cell death whose mechanism has been extensively studied …

Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however,
the metabolic substrates that autophagy provides to drive PDAC progression are unclear …

Oxidative stress and hypoxia in the retinal pigment epithelium (RPE) have long been
considered major risk factors in the pathophysiology of age-related macular degeneration …

Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron
cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc …

Cellular senescence is a hallmark of aging and has been linked to age-related diseases.
Age-related macular degeneration (AMD), the most common aging-related retinal disease …

Iron is an essential trace element that is involved in a variety of physiological processes.
Ferritinophagy is selective autophagy mediated by nuclear receptor coactivator 4 (NCOA4) …

Ferroptosis, an iron-dependent type of regulated cell death, is triggered by the accumulation
of lethal lipid peroxides. Due to its potential in exploring disease progression and highly …

Mammalian cochlea spiral ganglion neurons (SGNs) are crucial for sound transmission, they
can be damaged by chemotherapy drug cisplatin and lead to irreversible sensorineural …

NCOA4 is a selective cargo receptor for ferritinophagy, the autophagic turnover of ferritin
(FTH), a process critical for regulating intracellular iron bioavailability. However, how …