Twenty years ago, the discovery of peptides able to cross cellular membranes launched a
novel field in molecular delivery based on these non-invasive vectors, most commonly …

The permeability barrier imposed by cellular membranes limits the access of exogenous
compounds to the interior of cells. Researchers and patients alike would benefit from …

Previous cell-penetrating peptides (CPPs) generally have low cytosolic delivery efficiencies,
because of inefficient endosomal escape. In this study, a family of small, amphipathic cyclic …

One of the major obstacles in intracellular targeting using antibodies is their limited release
from endosomes into the cytosol. Here we report an approach to deliver proteins, which …

Successful cytosolic delivery of nanomaterials is becoming more and more important, given
the increase in intracellular applications of quantum dots, gold nanoparticles, liposomal drug …

The ability of cell-penetrating peptides (CPPs) to cross cell membranes has found numerous
applications in the delivery of bioactive compounds to the cytosol of living cells. Their …

Modulating the tumor immune microenvironment to activate immune cells has been
investigated to convert cold to hot tumors. Here, we report that metal–lipid hybrid …

The delivery of therapeutic agents faces significant hurdles posed by the endo-lysosomal
pathway, a bottleneck that hampers clinical effectiveness. This comprehensive review …

The limitations imposed on brain therapy by the blood–brain barrier (BBB) have warranted
the development of carriers that can overcome and deliver therapeutic agents into the brain …

Positively charged antimicrobial peptides have become promising agents for the treatment
of cancer by inducing apoptosis though their preferential binding and disruption of …