Neutrophils are major effectors and regulators of the immune system. They play critical roles
not only in the eradication of pathogens but also in cancer initiation and progression …

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal
tract that results from dysfunction in innate and/or adaptive immune responses. Impaired …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …

Neutrophils are increasingly recognized as key players in the tumor immune response and
are associated with poor clinical outcomes. Despite recent advances characterizing the …

Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with
perplexing heterogeneity in disease manifestation and response to treatment. While the …

Neutrophils are formidable defenders. Their vast numbers, constant production, high
cytotoxicity and capacity to produce extracellular traps, underlie their ability to efficiently …

Critically ill patients in intensive care units experience profound alterations of their gut
microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections …

Neutrophils, the most abundant innate immune cells, function as crucial regulators of the
adaptive immune system in diverse pathological conditions, including metastatic cancer …

Aging accounts for increased risk and dismal outcome of ischemic stroke. Here, we
investigated the impact of age-related changes in the immune system on stroke. Upon …

Neutrophil extracellular traps (NETs) evolved to protect the host against microbial infections
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …