[HTML][HTML] Garbage in, garbage out: a critical evaluation of strategies used for validation of immunohistochemical biomarkers
G O'Hurley, E Sjöstedt, A Rahman, B Li, C Kampf… - Molecular …, 2014 - Elsevier
The use of immunohistochemistry (IHC) in clinical cohorts is of paramount importance in
determining the utility of a biomarker in clinical practice. A major bottleneck in translating a …
determining the utility of a biomarker in clinical practice. A major bottleneck in translating a …
Long-chain acyl-CoA esters in metabolism and signaling: role of acyl-CoA binding proteins
D Neess, S Bek, H Engelsby, SF Gallego… - Progress in lipid …, 2015 - Elsevier
Long-chain fatty acyl-CoA esters are key intermediates in numerous lipid metabolic
pathways, and recognized as important cellular signaling molecules. The intracellular flux …
pathways, and recognized as important cellular signaling molecules. The intracellular flux …
GENT2: an updated gene expression database for normal and tumor tissues
Abstract Background Gene Expression database of Normal and Tumor tissues 2 (GENT2) is
an updated version of GENT, which has provided a user-friendly search platform for gene …
an updated version of GENT, which has provided a user-friendly search platform for gene …
Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics
Global classification of the human proteins with regards to spatial expression patterns
across organs and tissues is important for studies of human biology and disease. Here, we …
across organs and tissues is important for studies of human biology and disease. Here, we …
[HTML][HTML] Synonymous mutations frequently act as driver mutations in human cancers
Synonymous mutations change the sequence of a gene without directly altering the
sequence of the encoded protein. Here, we present evidence that these" silent" mutations …
sequence of the encoded protein. Here, we present evidence that these" silent" mutations …
An expression atlas of human primary cells: inference of gene function from coexpression networks
Background The specialisation of mammalian cells in time and space requires genes
associated with specific pathways and functions to be co-ordinately expressed. Here we …
associated with specific pathways and functions to be co-ordinately expressed. Here we …
[HTML][HTML] A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
The rat has been used extensively as a model for evaluating chemical toxicities and for
understanding drug mechanisms. However, its transcriptome across multiple organs, or …
understanding drug mechanisms. However, its transcriptome across multiple organs, or …
TISSUES 2.0: an integrative web resource on mammalian tissue expression
Physiological and molecular similarities between organisms make it possible to translate
findings from simpler experimental systems—model organisms—into more complex ones …
findings from simpler experimental systems—model organisms—into more complex ones …
Functional dissection of the enhancer repertoire in human embryonic stem cells
Enhancers are genetic elements that regulate spatiotemporal gene expression. Enhancer
function requires transcription factor (TF) binding and correlates with histone modifications …
function requires transcription factor (TF) binding and correlates with histone modifications …
Unifying cancer and normal RNA sequencing data from different sources
Driven by the recent advances of next generation sequencing (NGS) technologies and an
urgent need to decode complex human diseases, a multitude of large-scale studies were …
urgent need to decode complex human diseases, a multitude of large-scale studies were …