Microbiome and human health: current understanding, engineering, and enabling technologies
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
Engineered living materials for sustainability
Recent advances in synthetic biology and materials science have given rise to a new form of
materials, namely engineered living materials (ELMs), which are composed of living matter …
materials, namely engineered living materials (ELMs), which are composed of living matter …
A programmable encapsulation system improves delivery of therapeutic bacteria in mice
Living bacteria therapies have been proposed as an alternative approach to treating a broad
array of cancers. In this study, we developed a genetically encoded microbial encapsulation …
array of cancers. In this study, we developed a genetically encoded microbial encapsulation …
Engineering living therapeutics with synthetic biology
The steadfast advance of the synthetic biology field has enabled scientists to use genetically
engineered cells, instead of small molecules or biologics, as the basis for the development …
engineered cells, instead of small molecules or biologics, as the basis for the development …
[HTML][HTML] Game changers in science and technology-now and beyond
The recent devastating pandemic has drastically reminded humanity of the importance of
constant scientific and technological progress. A strong interdisciplinary dialogue between …
constant scientific and technological progress. A strong interdisciplinary dialogue between …
Common principles and best practices for engineering microbiomes
Despite broad scientific interest in harnessing the power of Earth's microbiomes, knowledge
gaps hinder their efficient use for addressing urgent societal and environmental challenges …
gaps hinder their efficient use for addressing urgent societal and environmental challenges …
[HTML][HTML] Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut
JP Lynch, C González-Prieto, AZ Reeves, S Bae… - Cell Host & Microbe, 2023 - cell.com
Drug platforms that enable the directed delivery of therapeutics to sites of diseases to
maximize efficacy and limit off-target effects are needed. Here, we report the development of …
maximize efficacy and limit off-target effects are needed. Here, we report the development of …
Chemically and biologically engineered bacteria‐based delivery systems for emerging diagnosis and advanced therapy
Bacteria are one of the main groups of organisms, which dynamically and closely participate
in human health and disease development. With the integration of chemical biotechnology …
in human health and disease development. With the integration of chemical biotechnology …
Oral drug delivery platforms for biomedical applications
Oral administration is perhaps the most commonly used and acceptable route for drug
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …
Applications of synthetic biology in medical and pharmaceutical fields
X Yan, X Liu, C Zhao, GQ Chen - Signal transduction and targeted …, 2023 - nature.com
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …
bioproperties. During the past decades, progresses have been made to build delicate …