Microbiome and human health: current understanding, engineering, and enabling technologies

N Aggarwal, S Kitano, GRY Puah, S Kittelmann… - Chemical …, 2022 - ACS Publications
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …

Engineered living materials for sustainability

B An, Y Wang, Y Huang, X Wang, Y Liu, D Xun… - Chemical …, 2022 - ACS Publications
Recent advances in synthetic biology and materials science have given rise to a new form of
materials, namely engineered living materials (ELMs), which are composed of living matter …

A programmable encapsulation system improves delivery of therapeutic bacteria in mice

T Harimoto, J Hahn, YY Chen, J Im, J Zhang… - Nature …, 2022 - nature.com
Living bacteria therapies have been proposed as an alternative approach to treating a broad
array of cancers. In this study, we developed a genetically encoded microbial encapsulation …

Engineering living therapeutics with synthetic biology

A Cubillos-Ruiz, T Guo, A Sokolovska… - Nature Reviews Drug …, 2021 - nature.com
The steadfast advance of the synthetic biology field has enabled scientists to use genetically
engineered cells, instead of small molecules or biologics, as the basis for the development …

[HTML][HTML] Game changers in science and technology-now and beyond

UAK Betz, L Arora, RA Assal, H Azevedo… - … Forecasting and Social …, 2023 - Elsevier
The recent devastating pandemic has drastically reminded humanity of the importance of
constant scientific and technological progress. A strong interdisciplinary dialogue between …

Common principles and best practices for engineering microbiomes

CE Lawson, WR Harcombe, R Hatzenpichler… - Nature Reviews …, 2019 - nature.com
Despite broad scientific interest in harnessing the power of Earth's microbiomes, knowledge
gaps hinder their efficient use for addressing urgent societal and environmental challenges …

[HTML][HTML] Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut

JP Lynch, C González-Prieto, AZ Reeves, S Bae… - Cell Host & Microbe, 2023 - cell.com
Drug platforms that enable the directed delivery of therapeutics to sites of diseases to
maximize efficacy and limit off-target effects are needed. Here, we report the development of …

Chemically and biologically engineered bacteria‐based delivery systems for emerging diagnosis and advanced therapy

Z Li, Y Wang, J Liu, P Rawding, J Bu… - Advanced …, 2021 - Wiley Online Library
Bacteria are one of the main groups of organisms, which dynamically and closely participate
in human health and disease development. With the integration of chemical biotechnology …

Oral drug delivery platforms for biomedical applications

J Ouyang, Z Zhang, B Deng, J Liu, L Wang, H Liu… - Materials Today, 2023 - Elsevier
Oral administration is perhaps the most commonly used and acceptable route for drug
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …

Applications of synthetic biology in medical and pharmaceutical fields

X Yan, X Liu, C Zhao, GQ Chen - Signal transduction and targeted …, 2023 - nature.com
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …