Coeliac disease

K Lindfors, C Ciacci, K Kurppa, KEA Lundin… - Nature reviews Disease …, 2019 - nature.com
Coeliac disease is an immune-mediated enteropathy against dietary gluten present in
wheat, rye and barley and is one of the most common lifelong food-related disorders …

Redox signaling in the gastrointestinal tract

S Pérez, R Taléns-Visconti, S Rius-Pérez… - Free Radical Biology …, 2017 - Elsevier
Redox signaling regulates physiological self-renewal, proliferation, migration and
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …

Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease

V Dotsenko, B Tewes, M Hils, R Pasternack, J Isola… - Nature …, 2024 - nature.com
Abstract Transglutaminase 2 (TG2) plays a pivotal role in the pathogenesis of celiac disease
(CeD) by deamidating dietary gluten peptides, which facilitates antigenic presentation and a …

Nutritional wheat amylase-trypsin inhibitors promote intestinal inflammation via activation of myeloid cells

VF Zevallos, V Raker, S Tenzer, C Jimenez-Calvente… - Gastroenterology, 2017 - Elsevier
Background & Aims Wheat amylase-trypsin inhibitors (ATIs) are nutritional activators of
innate immunity, via activation of the toll-like receptor 4 (TLR4) on myeloid cells. We aimed …

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

A Luciani, VR Villella, S Esposito, N Brunetti-Pierri… - Nature cell …, 2010 - nature.com
Accumulation of unwanted/misfolded proteins in aggregates has been observed in airways
of patients with cystic fibrosis (CF), a life-threatening genetic disorder caused by mutations in …

Metabolic syndrome in patients with coeliac disease on a gluten‐free diet

R Tortora, P Capone, G De Stefano… - Alimentary …, 2015 - Wiley Online Library
Background Several studies have shown that weight changes are common in patients with
coeliac disease after starting a gluten‐free diet (GFD), but data on the prevalence of …

Celiac disease, inflammation and oxidative damage: a nutrigenetic approach

G Ferretti, T Bacchetti, S Masciangelo, L Saturni - Nutrients, 2012 - mdpi.com
Celiac disease (CD), a common heritable chronic inflammatory condition of the small
intestine caused by permanent intolerance to gluten/gliadin (prolamin), is characterized by a …

Chitosan oligosaccharide as potential therapy of inflammatory bowel disease: Therapeutic efficacy and possible mechanisms of action

M Yousef, R Pichyangkura, S Soodvilai… - Pharmacological …, 2012 - Elsevier
Inflammatory bowel disease (IBD) results from intestinal epithelial barrier defect and
dysregulated mucosal immune response. This study aimed to evaluate the therapeutic …

Gluten-free diet reduces adiposity, inflammation and insulin resistance associated with the induction of PPAR-alpha and PPAR-gamma expression

FLP Soares, R de Oliveira Matoso, LG Teixeira… - the Journal of nutritional …, 2013 - Elsevier
Gluten exclusion (protein complex present in many cereals) has been proposed as an
option for the prevention of diseases other than coeliac disease. However, the effects of …

Non-celiac gluten sensitivity: literature review

P Mansueto, A Seidita, A D'Alcamo… - Journal of the American …, 2014 - Taylor & Francis
Background: A significant percentage of the general population report problems caused by
wheat and/or gluten ingestion, even though they do not have celiac disease (CD) or wheat …