Acute lymphoblastic leukemia (ALL) is diagnosed in 3000 to 4000 persons in the United
States each year; two thirds of them are children. 1, 2 The current rate of cure of nearly 80 …

Chronic myelomonocytic leukemia (CMML) is a rare hematopoietic malignancy of childhood.
To define the clinical and hematologic characteristics of the disease, we performed a …

Abstract The Children's Cancer Group (CCG) and the Pediatric Oncology Group (POG)
joined to form the Children's Oncology Group (COG) in 2000. This merger allowed analysis …

By using rapid flow cytometric techniques capable of detecting one leukemic cell in 104
normal cells, we prospectively studied minimal residual disease (MRD) in 195 children with …

Abstract The Dana-Farber Cancer Institute (DFCI) Childhood ALL Consortium Protocol 95-
01 was designed to minimize therapy-related morbidity for children with newly diagnosed …

VER A DECADE HAS passed since ''Immunologic Classification of Leukemia and
Lymphoma''by Foon and Todd was published in Blood. 1 Over this decade, flow Acute …

The childhood leukemias are a study in contrasts. Acute lymphoblastic leukemia (ALL) is
diagnosed in approximately 2000 children in the United States each year, whereas acute …

This study of children and adults with acute lymphoblastic leukaemia (ALL) is the largest
series of patients with hypodiploidy (< 46 chromosomes) yet reported. The incidence of 5 …

The molecular approach for the analysis of leukemia associated chromosomal
translocations has led to the identification of prognostic relevant subgroups. In pediatric …

Background Therapy for childhood lymphoblastic leukemia has evolved during the past
three decades, but key questions about what are the least toxic, most effective forms of …