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Antimalarial drug discovery: progress and approaches
Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …
overcome emerging drug resistance, whilst considering safety and improving dosing …
The past, present and future of anti-malarial medicines
Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …
CRISPR-Cas9 system: A new-fangled dawn in gene editing
Till date, only three techniques namely Zinc Finger Nuclease (ZFN), Transcription-Activator
Like Effector Nucleases (TALEN) and Clustered Regularly Interspaced Short Palindromic …
Like Effector Nucleases (TALEN) and Clustered Regularly Interspaced Short Palindromic …
Malaria: biology and disease
Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …
cause of death and disease across many tropical and subtropical countries. Over the last …
Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
Rapid, selective heavy metal removal from water by a metal–organic framework/polydopamine composite
Drinking water contamination with heavy metals, particularly lead, is a persistent problem
worldwide with grave public health consequences. Existing purification methods often …
worldwide with grave public health consequences. Existing purification methods often …
Antimalarial drug resistance: a threat to malaria elimination
Increasing antimalarial drug resistance once again threatens effective antimalarial drug
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …
New developments in anti-malarial target candidate and product profiles
A decade of discovery and development of new anti-malarial medicines has led to a
renewed focus on malaria elimination and eradication. Changes in the way new anti …
renewed focus on malaria elimination and eradication. Changes in the way new anti …
Malaria medicines: a glass half full?
TNC Wells, RH Van Huijsduijnen… - Nature Reviews Drug …, 2015 - nature.com
Despite substantial scientific progress over the past two decades, malaria remains a
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …
Drugs in development for malaria
The last two decades have seen a surge in antimalarial drug development with product
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …