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Ectopic JAK–STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance
Emerging evidence indicates that various cancers can gain resistance to targeted therapies
by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations …
by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations …
[HTML][HTML] Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer
Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …
ZNF397 deficiency triggers TET2-driven lineage plasticity and AR-targeted therapy resistance in prostate cancer
Cancer cells exhibit phenotypical plasticity and epigenetic reprogramming that allows them
to evade lineage-dependent targeted treatments by adopting lineage plasticity. The …
to evade lineage-dependent targeted treatments by adopting lineage plasticity. The …
Androgen receptor post-translational modifications and their implications for pathology
I Montoya-Novoa… - Biochemical Society …, 2024 - portlandpress.com
A major mechanism to modulate the biological activities of the androgen receptor (AR)
involves a growing number of post-translational modifications (PTMs). In this review we …
involves a growing number of post-translational modifications (PTMs). In this review we …
Personalized Medicine: Leave no Patient Behind; Report From the 2024 Coffey‐Holden Prostate Cancer Academy Meeting
ABSTRACT Introduction The 11th Annual 2024 Coffey‐Holden Prostate Cancer Academy
(CHPCA) Meeting, was themed “Personalized Medicine: Leave No Patient Behind,” and was …
(CHPCA) Meeting, was themed “Personalized Medicine: Leave No Patient Behind,” and was …
Restoring our ubiquitination machinery to overcome resistance in cancer therapy
The ubiquitin-proteasome system (UPS)[1], which is usually responsible for regulating
protein degradation, is important for cellular homeostasis, and playing a crucial role in …
protein degradation, is important for cellular homeostasis, and playing a crucial role in …
[HTML][HTML] UBE2J1 Is the E2 Ubiquitin-Conjugating Enzyme Regulating Androgen Receptor Degradation and Antiandrogen Resistance-Beyond the Abstract
Prostate cancer (PCa) remains a leading cause of cancer-related morbidity and mortality
among men. The emergence of resistance to antiandrogen therapies poses a significant …
among men. The emergence of resistance to antiandrogen therapies poses a significant …
Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation-Beyond the Abstract
The advancement of targeted cancer therapies has markedly changed cancer treatment,
offering more personalized and efficient solutions. However, the varied responses among …
offering more personalized and efficient solutions. However, the varied responses among …