Leishmaniasis, usually caused by the genus Leishmania, has not received the attention it
deserves and in recent times has developed into a major health problem worldwide. 1, 2 …

Leishmania, one of the most important neglected tropical diseases, is endemic in several
regions of the world and hence regarded as a serious threat to public health. Major …

A series of new 6-quinolinyl and quinolinyl N-oxide chalcones were efficiently prepared. All
chalcones were tested by minimal inhibitory concentration (MIC) against three species of …

A green method was developed for the synthesis of chalcones using glycerin as solvent.
Subsequently, the potential microbiology activity of these molecules was evaluated by …

In this work, the SOFT. PTML tool has been used to pre-process a ChEMBL dataset of pre-
clinical assays of antileishmanial compound candidates. A comparative study of different ML …

Vascular endothelial growth factor Receptor-2 (VEGFR-2) kinase inhibition is one of the well
established strategies to promptly tackle tumor growth by suppression of angiogenesis. In …

ABSTRACT A series of 9 quinolines and 18 styrylquinolines was evaluated for the drugs' in
vitro antileishmanial activities and cytotoxicities. The 7-aroylstyrylquinoline scaffold …

Cholinesterases (ChEs) play a vital role in regulating cholinergic transmission. Inhibition of
ChEs is thought to be an emerging and useful therapeutic target for neurodegenerative …

Chalcones, ie, compounds with the chemical pattern of 1, 3-diphenylprop-2-en-1-ones, exert
a wide range of bio-activities, eg, antioxidant, anti-inflammatory, anticancer, anti-infective …

The increasing resistance of bacteria and fungi to antimicrobial drugs has been a matter of
concern in public health in the last decades. The continuing need for novel therapeutic …