Tumor angiogenesis is necessary for the continued survival and development of tumor cells,
and plays an important role in their growth, invasion, and metastasis. The tumor …

Simple Summary Immunotherapies have revolutionized the field of cancer therapeutics, yet
a substantial subset of patients fail to respond. Recent efforts have focused on identifying …

Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …

Over the past decade, preclinical and clinical research have confirmed the essential role of
interferons for effective host immunological responses to malignant cells. Type I interferons …

Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to
address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted …

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) expression correlates with
poor prognosis in many cancers, and we previously discovered that ENPP1 is the dominant …

These guidelines update previous guidance published in 2005. They have been revised by
a group who are members of the UK and Ireland Neuroendocrine Tumour Society with …

The family of interferon (IFN) proteins has now more than reached the potential envisioned
by early discovering virologists: IFNs are not only antivirals with a spectrum of clinical …

During the last decades, the pleiotropic antitumor functions exerted by type I interferons
(IFNs) have become universally acknowledged, especially their role in mediating …

Angiogenesis is a multi-stage process of new blood vessel development from pre-existing
vessels toward an angiogenic stimulus. The process is essential for tissue maintenance and …