Dietary carcinogens and anticarcinogens: oxygen radicals and degenerative diseases
BN Ames - Science, 1983 - science.org
The human diet contains a great variety of natural mutagens and carcinogens, as well as
many natural antimutagens and anticarcinogens. Many of these mutagens and carcinogens …
many natural antimutagens and anticarcinogens. Many of these mutagens and carcinogens …
Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches
An overview is presented on the molecular aspects of toxicity due to paracetamol
(acetaminophen) and structural analogues. The emphasis is on four main topics, that is …
(acetaminophen) and structural analogues. The emphasis is on four main topics, that is …
N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.
DC Dahlin, GT Miwa, AY Lu… - Proceedings of the …, 1984 - National Acad Sciences
N-acetyl-p-benzoquinone imine (NAPQI) has been proposed as the toxic metabolite of
acetaminophen for the past 10 years, although it has never been detected as an enzymatic …
acetaminophen for the past 10 years, although it has never been detected as an enzymatic …
Differential distribution of glutathione and glutathione-related enzymes in rabbit kidney: possible implications in analgesic nephropathy
J Mohandas, JJ Marshall, GG Duggin… - Biochemical …, 1984 - Elsevier
Whole tissue reduced glutathione (GSH) concentration was found to be lowest in rabbit
renal inner medulla and progressively higher in outer medulla and cortex. Activities of …
renal inner medulla and progressively higher in outer medulla and cortex. Activities of …
Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention
Paracetamol (N-acetyl-p-aminophenoi, Fig. I), also known as acetaminophen. was first
described as an analgesic and antipyretic agent by Von Mering in 1893 [l]. In the 1940s …
described as an analgesic and antipyretic agent by Von Mering in 1893 [l]. In the 1940s …
Three models of free radical-induced cell injury
M Comporti - Chemico-biological interactions, 1989 - Elsevier
Three models of free radical-induced cell injury are presented in this review. Each model is
described by the mechanism of action of few prototype toxic molecules. Carbon tetrachloride …
described by the mechanism of action of few prototype toxic molecules. Carbon tetrachloride …
[HTML][HTML] Hepatocyte-specific Mas activation enhances lipophagy and fatty acid oxidation to protect against acetaminophen-induced hepatotoxicity in mice
Background & Aims Acetaminophen (APAP) is the most common cause of drug-induced
liver injury (DILI); however, treatment options are limited. Mas is a G protein-coupled …
liver injury (DILI); however, treatment options are limited. Mas is a G protein-coupled …
Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivoin mice using two-dimensional gel electrophoresis and mass spectrometry
Liver toxicity following an overdose of acetaminophen is frequently considered a model for
drug-induced hepatotoxicity. Extensive studies over many years have established that such …
drug-induced hepatotoxicity. Extensive studies over many years have established that such …
Drug bioactivation covalent binding to target proteins and toxicity relevance
A number of therapeutic drugs with different structures and mechanisms of action have been
reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes …
reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes …
Acetaminophen hepatotoxicity.
M Black - Annual review of medicine, 1984 - europepmc.org
This review of acetaminophen hepatotoxicity begins with a history of the drug and
consideration of the scope of its current use. The molecular basis for hepatotoxicity is …
consideration of the scope of its current use. The molecular basis for hepatotoxicity is …