Substance use disorders (SUD) and drug addiction are major threats to public health,
impacting not only the millions of individuals struggling with SUD, but also surrounding …

The tools of modern genetics and neurobiology have propelled a renaissance of research
that has advanced our understanding of the pathophysiology of drug addiction. We know …

Opioid use disorder (OUD) looms as one of the most severe medical crises facing society.
More effective therapeutics will require a deeper understanding of molecular changes …

Dynamic interactions of neurons and glia in the ventral midbrain mediate reward and
addiction behavior. We studied gene expression in 212,713 ventral midbrain single nuclei …

Cocaine use disorder (CUD) is a chronic neuropsychiatric condition that results from
enduring cellular and molecular adaptations. Among substance use disorders, CUD is …

Opioid craving and relapse vulnerability is associated with severe and persistent sleep and
circadian rhythm disruptions. Understanding the neurobiological underpinnings of circadian …

Methamphetamine use disorder (MUD) is characterized by loss of control over compulsive
drug use. Here, we used a self-administration (SA) model to investigate transcriptional …

Cocaine use disorder is a significant public health issue without an effective
pharmacological treatment. Successful treatments are hindered in part by an incomplete …

Preclinical and clinical studies indicate that psychostimulants, in addition to having abuse
potential, may elicit brain dysfunctions and/or neurotoxic effects. Central toxicity induced by …

Structural and functional changes of the brain are assumed to contribute to excessive
cocaine intake, craving, and relapse in cocaine use disorder (CUD). Epigenetic and …