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Bioactive compounds in oxidative stress-mediated diseases: targeting the NRF2/ARE signaling pathway and epigenetic regulation
Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …
Botanicals and their bioactive phytochemicals for women's health
BM Dietz, A Hajirahimkhan, TL Dunlap… - Pharmacological …, 2016 - Elsevier
Botanical dietary supplements are increasingly popular for women's health, particularly for
older women. The specific botanicals women take vary as a function of age. Younger …
older women. The specific botanicals women take vary as a function of age. Younger …
NRF2-regulation in brain health and disease: implication of cerebral inflammation
The nuclear factor erythroid 2 related factor 2 (NRF2) is a key regulator of endogenous
inducible defense systems in the body. Under physiological conditions NRF2 is mainly …
inducible defense systems in the body. Under physiological conditions NRF2 is mainly …
[HTML][HTML] Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
M Matzinger, K Fischhuber, EH Heiss - Biotechnology advances, 2018 - Elsevier
Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …
Nrf2—a promising therapeutic target for defensing against oxidative stress in stroke
R Zhang, M Xu, Y Wang, F **e, G Zhang, X Qin - Molecular Neurobiology, 2017 - Springer
Stroke is one of the leading causes of death and disability in the world. Oxidative stress,
which refers to an excessive generation of reactive oxygen species (ROS), plays a key role …
which refers to an excessive generation of reactive oxygen species (ROS), plays a key role …
[HTML][HTML] Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Neurodegenerative diseases are linked to the accumulation of specific protein aggregates,
suggesting an intimate connection between injured brain and loss of proteostasis …
suggesting an intimate connection between injured brain and loss of proteostasis …
Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells
Luteolin, a dietary flavone, modulates various signaling pathways involved in
carcinogenesis. In this study, we investigated the molecular mechanism that underlies the …
carcinogenesis. In this study, we investigated the molecular mechanism that underlies the …
Anticancer activity of sulforaphane: the epigenetic mechanisms and the Nrf2 signaling pathway
Sulforaphane (SFN), a compound derived from cruciferous vegetables that has been shown
to be safe and nontoxic, with minimal/no side effects, has been extensively studied due to its …
to be safe and nontoxic, with minimal/no side effects, has been extensively studied due to its …
Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals
Keap1/Nrf2 system plays a critical role on cellular protection by regulating many antioxidant
and detoxification enzyme genes through the antioxidant response element (ARE). Thus, it …
and detoxification enzyme genes through the antioxidant response element (ARE). Thus, it …
Epigenetic regulation of Keap1-Nrf2 signaling
The kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2
(Nrf2) signaling axis serves as a “master regulator” in response to oxidative/electrophilic …
(Nrf2) signaling axis serves as a “master regulator” in response to oxidative/electrophilic …