Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …

An incomplete view of the mechanisms that drive metastasis, the primary cause of cancer-
related death, has been a major barrier to development of effective therapeutics and …

The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages
of RNA metabolism and participates in the progression of many diseases, including virus …

Cytosolic ribosomes (cytoribosomes) are macromolecular ribonucleoprotein complexes that
are assembled from ribosomal RNA and ribosomal proteins, which are essential for protein …

Sex differences are pervasive in human health and disease. One major key to sex-biased
differences lies in the sex chromosomes. Although the functions of the X chromosome …

De novo germline mutations in the RNA helicase DDX3X account for 1%–3% of
unexplained intellectual disability (ID) cases in females and are associated with autism …

Phenotypic and metabolic heterogeneity within tumors is a major barrier to effective cancer
therapy. How metabolism is implicated in specific phenotypes and whether lineage …

The human DEAD-box protein DDX3X is an RNA remodelling enzyme that has been
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …

Abstract Background Long noncoding RNAs (lncRNAs) have emerged as key regulators in
multiple cancers, including colorectal cancer (CRC). However, the biological functions and …