The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery
of genes involved in the metabolism of xenobiotics and endogenous compounds. AhR is a …

The pregnane X receptor (PXR) is a kind of orphan nuclear receptor activated by a series of
ligands. Environmental endocrine disruptors (EEDs) are a wide class of molecules present …

Background Osteoarthritis (OA) is a common chronic disease characterized by chronic
inflammation and extracellular matrix degradation. Indole-3-propionic acid (IPA) is a …

Polyhalogenated carbazoles (PHCZs) are dioxin-like emerging contaminants, but limited
information exists on their neurotoxicity and mechanisms. This study employed zebrafish …

The mammalian family of basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) transcription
factors possess the ability to sense and respond to diverse environmental and physiological …

In recent years, natural products have gradually become an important source for new drug
development due to their advantages of multi-components, multi-targets, and good safety …

Dioxins are a group of chemicals not only regarded as highly toxic trace environmental
contaminants, but also considered typical contaminants in food. Dioxins spread across the …

Tetrabromobisphenol A (TBBPA) is a widely used plastic additive with high bioaccumulation
potential and toxicity on both humans and wildlife. Currently, research on its ecotoxicity and …

Background Osteoarthritis (OA) is a degenerative disease characterized by chronic
inflammation. Indole-3-aldehyde (3-IAld) is a tryptophan metabolite secreted by intestinal …

This research examines the levels and trends of pollutants, specifically 17 congeners of
PCDD/Fs and 12 dl-PCBs, in the air measured in the province of Gipuzkoa (Basque Country …